Brain Circuits Split Food Choices Between Sugar and Fat Cravings
A new study reveals that the brain uses two distinct neural pathways to regulate sugar and fat intake. In mice, glucoprivation—a drop in blood sugar levels—activates separate circuits in the hypothalamus: AMPK-regulated CRH neurons drive high-carbohydrate consumption, while MC4R-expressing neurons promote high-fat food intake. These pathways are triggered by NPY neurons in the brainstem, which respond to energy deficits. The discovery sheds light on how the brain distinguishes between nutrient types when balancing energy needs, offering clues for treating overeating and metabolic disorders. ….[READ]
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